Combinatorial stresses kill pathogenicCandidaspecies

Combinatorial stresses kill pathogenic Candida species

Pathogenic microbes exist in dynamic niches and have evolved robust adaptive responses to promote survival in their hosts. The major fungal pathogens of humans, Candida albicans and Candida glabrata, are exposed to a range of environmental stresses in their hosts including osmotic, oxidative and nitrosative stresses. Significant efforts have been devoted to the characterization of the adaptive ...

Considering Stochastic and Combinatorial Optimization

Here, issues connected with characteristic stochastic practices are considered. In the first part, the plausibility of covering the arrangements of an improvement issue on subjective subgraphs is studied. The impulse for this strategy is a state where an advancement issue must be settled as often as possible for discretionary illustrations. Then, a preprocessing stage is considered that would q...

DNA vaccines and apoptosis: to kill or not to kill?

The Journal of Clinical Investigation | July 2003 | Volume 112 | Number 1 RNase. Proc. Natl. Acad. Sci. U. S. A. 100:4102-4107. 14. Shinkura, R., et al. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:435–441. 15. Yu, K., Chedin, F., Hsieh, C.L., Wilson, T.E., and Lieber, M.R. 2003. R-loops at immunoglobulin class switch regions in the ch...

Do genes allow inflammation to kill or not to kill?

A lysin to kill

An enzyme produced by a bacteriophage can enter human cells and kill intracellular Streptococcus pyogenes.